Method of making a hair growth product

ABSTRACT

A composition and method for treating hair loss is disclosed. The composition comprises water-soluble ionizable metal and non-metal components, aqueous and alcohol-based solvents, potassium iodide and citrus essential oil, and is preferably provided as a non-aerosol spray product that is applied to the hair and scalp. The invention further provides a method of making and using the composition.

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a continuation-in-part of U.S. application Ser. No.14/973,368, filed Dec. 17, 2015.

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

Not applicable.

TECHNICAL FIELD OF INVENTION

This invention relates to the field of treatment of hair loss.

BACKGROUND OF THE INVENTION

Hair loss is a common condition in humans. While not a physicallyinjurious condition, hair loss can be a source of stress or anxiety formany individuals. There are numerous causes for hair loss includingheredity, nutritional deficiencies, hormone imbalances, auto-immunedisorders, chemotherapy, and stress, among others. Methods to remedyhair loss have involved treatments of antimicrobial compositions,aromatic oils, cortisol blockers, nutritional supplements, treatments toimprove the appearance of thinning hair and many other treatmentcompositions.

The hair loss remediation methods have varying levels of successdepending on the primary reason for the hair loss in the individualalong with the compliance of the individual in using a particular remedyfor the requisite period. There are many potential causes of hair loss,which means there also are many potential routes to remedy each cause ofhair loss.

For instance, some remedies may provide vitamin, mineral or oilsupplements to the body, which can enhance hair growth retarded bycertain hair loss problems. Also, compliance with a method of treatmentcan be a factor for many individuals. Treatments that promote hairgrowth generally take a number of months to achieve the desired resultsdue to the length of time associated with hair growth and rest cycles.Products which are difficult or unpleasant to use may cause anindividual to stop using a potentially effective composition before thecomposition has had adequate time to work. Difficulties, such ascomplicated application procedures, products that make the hair greasyor hard to style, products that make the scalp area itch or that have anunpleasant odor, are all reasons an individual might not continue to usea hair loss remedy.

Many compositions and methods have been suggested to remedy hair loss bypromoting hair growth and/or enhancing the appearance of hair. Theseknown methods include the following prior art references.

U.S. Patent Publication No, 2015/0079141 to Wingfield is entitled“Chelated Metal Oxide Gel Compositions” and describes a composition ofchelated metals that has antimicrobial and antiviral effects primarilyutilizing chelated silver oxide along with other antimicrobialingredients which may be included in many types of products includingproducts for hair.

U.S. Patent Application Publication No. 2013/0115183 to Ko is entitled“Method of Preparing Hair and Scalp Conditioning Compositions includingAromatic Oil Blend with Enhanced Efficacy” and describes the use of acombination of aromatic oils for prevention of hair loss.

U.S. Patent Application Publication No. 2012/0263660 to Altschul et al.is entitled “Hair Loss Treatment” and describes the use of cortisolblockers for prevention of stress induced hair loss.

U.S. Patent Application Publication No. 2011/0195039 to Isaacs isentitled “Hair Building Solid Agent” and describes a hair spraycomposition that electrostatically binds to the hair to achieve athickened appearance.

U.S. Patent Application Publication No. 2008/0275118 to Shaw et al. isentitled “Health and Cosmetic Composition and Regime for StimulatingHair Growth and Thickening on the Head, Including the Scalp, Eyelashesand Eyebrows, and which Discourages Hair Loss” and describes acomposition for stimulating hair growth in mammals which may includeprostaglandins, prostaglandin analogs and combinations thereof.

U.S. Patent Application Publication No. 2007/0231377 to Abou-Nemeh isentitled “Compositions for Promoting Hair Growth” and describescompositions containing methionine analogs and derivatives for promotinghair growth.

U.S. Pat. No. 8,865,144 to Constantinides et al. is entitled “PersonalCare Compositions Comprising Responsive Particles” and describescompositions for personal care having polymer based responsiveparticles.

U.S. Pat. No. 8,715,714 to Kim et al. is entitled “Use of Rare EarthElements for Hair Improvement” and describes the use of rare earthmetals to promote hair growth and treat dandruff.

U.S. Pat. No. 6,800,276 to Kim et al. is entitled “Polyureas andWater-Soluble or Water-Dispersible Polymeric Salts” and describespolymer based cosmetic and pharmaceutical compositions.

Scott's Miracle-Gro® All Purpose Plant Food is a water soluble plantfood comprising nitrogen, phosphorus, and potassium in an approximateratio of 3:1:2 with trace quantities of iron, copper, zinc, manganese,boron, and molybdenum. Scott's Miracle-Gro® African Violet Plant Food isa liquid plant food comprising nitrogen, phosphorus, and potassium in anapproximate ratio of 1:1:1 with trace quantities of iron, copper, zinc,manganese, and boron. Miracle-Gro is a registered trademark of TheScotts Miracle-Gro Company.

There exists a need for an effective hair loss composition that istopically active and easy for an individual to use regularly for therequisite period of time to achieve the desired hair growth resultswithout producing unwanted side effects, such as oily or unmanageablehair.

SUMMARY OF THE INVENTION

A composition and method for treatment of hair loss is disclosed that isan effective hair loss composition that is topically active and easy foran individual to use regularly for the requisite period of time toachieve the desired hair growth results without producing unwanted sideeffects, such as oily or unmanageable hair. The composition comprises acombination of metal and non-metal ions, short chain alcohols and citrusoils. Preferably the composition is formulated as a hair spray fortopical application to the scalp, and the metal ions are preferablyprovided as either water soluble salts or chelated complexes.

A new treatment composition for hair loss is prepared comprising thesteps of dissolving or solubilizing treatment components in an aqueoussolution, mixing the solubilized components with an alcohol-basedsolvent, then diluting the mixture with an additional quantity of waterto achieve an effective concentration of the active components. Thecomposition is prepared as a non-aerosol hair spray and the hair sprayis applied to a user's scalp one to three times per day. A suitable hairspray base preferably comprises short-chain alcohols that are compatiblewith the treatment components. Additional components suitable for use ina hair spray, such as glycerin, stabilizing agents, or fragrances may beincluded in the composition.

In addition to promoting hair growth, the disclosed hair spraycomposition assists with removal of dandruff flakes from the hair andscalp. The hair spray formulation also works to control or manageflyaway hair.

In one embodiment the invention is a composition for treating hair losscomprising water-soluble ionizable metal and non-metal compoundssolubilized with aqueous and alcohol-based solvents, solubilizedpotassium iodide and citrus essential oil.

In another embodiment the invention is a method for making a compositionto treat hair loss comprising providing a dry combination ofwater-soluble ionizable metal and non-metal ionic compounds; mixing saiddry combination in a quantity of purified water until a solubilizedmixture forms; adding a quantity of a first component comprising analcohol-based solvent to said solubilized mixture with stirring; addinga quantity of a second component comprising solubilized potassium iodideand kelp extract to said solubilized mixture with stirring; and adding aquantity third of a third component comprising citrus essential oil tosaid solubilized mixture and stirring until components are fullysolubilized.

In yet another embodiment the invention is a method of hair losstreatment comprising the steps of providing a composition havingwater-soluble ionizable metal and non-metal compounds solubilized withaqueous and alcohol-based solvents, solubilized potassium iodide andcitrus essential oil as a non-aerosol spray composition; cleansing askin area in need of treatment; spraying a first coating of saidnon-aerosol spray composition to the skin treatment area, said coatingbeing light enough in volume that composition does not run off said skintreatment area; allowing said spray to dry on said skin treatment area;spraying a second coating of said non-aerosol spray composition to saidskin area, said coating being light enough in volume that compositiondoes not run off skin treatment area; allowing said second spray to dryon said skin area.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 is a photograph of the scalp crown area of User #1 after usingthe formulation for 2 years.

FIG. 2 is a photograph of the frontal area of the scalp of User #1 afterusing the formulation for 2 years.

DETAILED DESCRIPTION

A composition for treating hair loss along with a method for making andusing the composition is herein disclosed. The composition comprises acombination of metal and non-metal ions, short chain alcohols and citrusoils. Preferably the composition is formulated as a hair spray fortopical application to the scalp, and the metal ions are preferablyprovided as either water soluble salts or chelated complexes. Thecomposition is particularly beneficial for treating hair loss on thescalp, but may be applied to other areas of the skin as well. Thecomposition is useful for remedying hair loss in both men and women.

The hair loss composition is preferably formulated as a hair spray forapplication to a user's scalp. Preferably the non-aerosol spray willdeliver the composition in a light mist to coat the treatment area insuch a manner that the composition remains on the treatment area withoutrunning off. In an alternative embodiment, the composition may beformulated as a liquid that is applied with a sponge or other means andmassaged into the scalp.

Hair growth on the human scalp follows a cycle with three phases—theanagen phase, the catagen phase and the telogen phase.

The anagen (or growth) phase varies by individual and may last anywherefrom 2-6 years. In this phase, a hair typically grows at a rate of about1.25 cm (0.5 inch) per month. Around 85%-90% of the hair on a typicalindividual's scalp will be in the anagen phase at any given point.

The catagen phase occurs after the anagen phase and during this phase,hair growth ceases. The hair follicle tightens around the hair shaft andthe hair root shrinks away from the hair. The catagen phase is atransitional phase lasting around from a few days to a few weeks. Around4%-5% of the hair on a typical individual's scalp will be in the catagenphase.

During the last or telogen phase, the hair is released from the hairfollicle and will eventually fall away from the scalp. After the hair isreleased, the hair follicle enters a resting phase for around threemonths. Following this resting phase, the hair growth cycle starts againwith the anagen (growth) phase. Around 6%-10% of the hair on a typicalindividual's scalp will be in the telogen phase. Approximately 80-100hairs are shed each day, typically just prior to the anagen or growthphase beginning.

Application of the hair loss composition should continue for severalmonths to ensure that all of the hair follicles in the treatment areaare in contact with the hair loss composition through all three phasesof the hair growth cycle for at least one cycle and preferably throughmore than one cycle. The hair loss composition is preferably applied toa user's scalp one to three times per day for at least six months todetermine efficacy for an individual user.

Preparation of Exemplary Hair Loss Formulations

The hair loss composition invention can be prepared starting with themetal and non-metal ionic components in either a dry form or in asolubilized form. Additional active components are mixed with the ioniccompounds and the formulation is diluted to the final volume.

Exemplary Formulation 1—Preparation of Formulation from Dry Components

The formulation of a preferred hair spray composition with the ioniccomponents in a dry form is exemplified below. A dry compositioncontaining metal and non-metal ions is mixed with a quantity of purifiedwater, then mixed with a quantity of alcohol-based solvent. Theresultant mixture is combined with a quantity of a solution havingsolubilized iodine and kelp extract. A quantity of citrus oil is thenadded to the mixture. Purified water is added to the mixture to reachthe final volume desired. Exemplary Formulation 1 will have a finalvolume of 750 m L.

Step 1: Dry Components

Metal and nonmetal ions useful for the claimed hair product are providedin a dry composition comprised of water-soluble and chelated compoundsas characterized in Table I below.

TABLE I Ingredient Total Nitrogen, total    24% Ammoniacal nitrogen 3.5%(as ammonium sulfate) Urea nitrogen 20.5% (as urea and urea phosphate)Phosphate, available (as potassium phosphate)    8% Potassium, soluble(as potash (potassium oxide)    16% and potassium chloride) Boron (asboric acid)  0.02% Copper (Cu), soluble (as copper sulfate)  0.07% Iron(Fe), chelated (as EDTA-Fe)  0.10% Manganese (Mn), chelated (as EDTA-Mn) 0.05% Molybdenum (Mo), (as sodium molybdate) 0.0005% Zinc (Zn), soluble(as zinc sulfate)  0.06%

The dry composition of metal and non-metal ions contains excipientingredients such as binders, thickening agents, and stabilizing agentsand combination thereof. The excipient ingredients provide bulk to thedry composition and help to maintain the components in a powder orgranular state prior to mixing. The excipient ingredients also assistwith solubilizing, suspending or thickening the ionic components afterthe dry components are solubilized. Stabilizing agents may also increaseshelf-life by inhibiting microbial growth in the formulation ofsolubilized components.

Binders, thickening agents and stabilizing agents are selected frommaterials that will not react with the metal and non-metal iconiccomponents and which are suitable for a topical skin formulation.Materials may be selected from natural and synthetic water-solublepolymers, soluble silicates, polysaccharides, gums, celluloses, clays,and combinations thereof. Suitable materials include xanthan gum, acaciagum (gum Arabic), guar gum, carrageenan, alginic acid, hydroxyethylcellulose, methyl cellulose, pectin, starch (rice, wheat or cornderived), aluminum monostearate, polyethylene glycol, sodium silicate,sodium bentonite and attapulgite. Other binders and stabilizing agentsthat are suitable for topical application and which do not react withthe metal and non-metal ionic components may be used in addition to orinstead of the agents listed herein.

The concentration of binders and stabilizers is adjusted to achieve asuitable topical formulation that will decrease run-off of thecomposition from the treatment area, and may vary as needed to achieve aviscosity suitable for a composition formulated as a non-aerosol sprayor for a liquid or gel formulation applied by sponge or otherapplication means to the skin treatment area.

Step 2: Solubilizing Dry Components

20 grams to 40 grams of the dry composition characterized in Table Iabove is vigorously mixed with 60 mL to 120 mL (2-4 ounces) of purifiedwater to solubilize the components. Up to an additional 60 mL to 120 mLof purified water may be added a few milliliters at a time if necessaryto fully solubilize the components. The solubilized mixture is thencombined with 60 mL to 120 mL of alcohol-based solvent and stirred untila uniform mixture results.

The preferred alcohol-based solvent comprises a short chain alcohol thatcan be safely applied to human skin. The percentage of short chainalcohol in the alcohol-based solvent is preferably 50% to 70% by volumewith the remaining volume comprising purified water. The short chainalcohol is preferably selected from ethyl alcohol, isopropyl alcohol,and combinations thereof. The ethyl alcohol, isopropyl alcohol, andcombinations thereof, may further comprise 0.5% methyl salicylate(wintergreen oil). Preferably, the short chain alcohol is 70% isopropylalcohol. In a most preferred embodiment, the isopropyl alcohol furthercomprises 0.5% methyl salicylate (wintergreen oil).

Step 3: Addition of Remaining Active Components

A quantity of a solution having solubilized potassium iodide and kelpextract is added to the mixture prepared in Step 2 and stirred untilfully incorporated into the mixture. After the potassium iodide and kelpextract is incorporated into the mixture, a quantity of citrus oil isadded and stirred until fully incorporated.

A preferred solution containing potassium iodide and kelp extract hasapproximately 3-4 mg of solubilized potassium iodide and 40-45 mg ofkelp extract per milliliter of solution. An amount ranging from 2 mL to6 mL of the solubilized potassium iodide/kelp extract may added.

Citrus oil useful for the present formulation is preferably selectedfrom grapefruit essential oil, lemon essential oil, orange essentialoil, and combinations thereof. Preferably the citrus oil will haveapproximately 500 mg to 1000 mg of essential oil per milliliter. A finalconcentration range of 0.001% to 1.0% of essential oil may be used inthe formulation. More preferably, the final concentration is 0.1% to0.5% by volume.

Step 4: Addition of Purified Water to Finalize Volume

Purified water is added to the resultant mixture from Step 3 to reachthe desired final volume of 750 mL and the mixture is stirred to ensureeven distribution of the components throughout the composition.

Purified water useful for the composition may be deionized water,distilled water or water that has been filtered to remove particulatesand contaminates and would be considered potable. Preferably deionizedwater is used.

In one preferred embodiment of the hair loss formulation, 20 grams ofthe dry component mixture is combined with 60 mL purified water and 60mL of alcohol-based solvent. When the dry components are fullysolubilized, 4 mL of potassium iodide/kelp solution and 2 mL of a citrusessential oil are stirred into the mixture and purified water is addedto equal 750 mL.

In another preferred embodiment of the hair loss formulation, 40 gramsof the dry component mixture is combined with 120 mL purified water and120 mL of alcohol-based solvent. When the dry components are fullysolubilized, 6 mL of potassium iodide/kelp solution and 2 mL of a citrusessential oil are stirred into the mixture and purified water is addedto equal 750 mL.

Optional Components

Additional components suitable for use in a hair spray, such asglycerin, gums, water-soluble polymers, stabilizing agents, orfragrances may be optionally included in the hair loss formulation.Components to stabilize the formulation, improve texture and increaseshelf life, or fragrances to make it aesthetically agreeable, may beadded to the resultant mixture from Step 2 prior to the addition ofpurified water in Step 4. Purified water is then added to equal 750 mLof solution.

Exemplary Formulation 2—Preparation of Formulation from SolubilizedComponents

The composition of a preferred hair loss formulation prepared from ioniccomponents provided in a solubilized form is exemplified below. Asolubilized composition containing metal and non-metal ions is mixedwith a quantity of alcohol-based solvent. The resultant mixture iscombined with a quantity of a solution having solubilized iodine andkelp extract. A quantity of citrus oil is then added to the mixture withstirring. Purified water is added to the mixture to reach the finalvolume desired. Exemplary Formulation 2 will have a final volume of 750m L.

Step 1: Mixing Solubilized Components with Alcohol-Based Solvent

Metal and nonmetal ions useful for the claimed hair loss composition areprovided in a solubilized format comprised of soluble and chelatedcompounds as characterized in Table II below. The ionic compounds aresolubilized in an aqueous base.

TABLE II Ingredient Total Nitrogen, total   7% Ammoniacal nitrogen 0.4%(as ammonium sulfate) Urea nitrogen 6.6% (as urea) Phosphate, available(as potassium phosphate)   7% Potassium, soluble (as Potash (Potassiumoxide)   7% and Potassium chloride) Boron (as Boric acid) 0.02% Copper(Cu), soluble (as Cu-EDTA) 0.05% Iron (Fe), chelated (as Fe-HEEDTA)0.10% Manganese (Mn), chelated (as Mn-EDTA) 0.08% Zinc (Zn), soluble (asEDTA-Zn) 0.05%

A starting quantity of the solubilized ionic mixture of approximately500 mL is mixed combined with 60 mL to 120 mL of alcohol-based solventand stirred until a uniform mixture results. The solubilized ionicmixture is thoroughly mixed prior to measuring the starting andfinalizing volumes to ensure uniform distribution of the ioniccomponents.

The preferred alcohol-based solvent is a short chain alcohol that can besafely applied to human skin. The percentage of short chain alcohol inthe alcohol-based solvent is preferably 50% to 70% by volume with theremaining volume comprising purified water. The short chain alcohol isselected from ethyl alcohol, isopropyl alcohol and combinations thereof.The ethyl alcohol, isopropyl alcohol, and combinations thereof, mayfurther comprise 0.5% methyl salicylate (wintergreen oil). Preferably,the short chain alcohol is 70% isopropyl alcohol. In a most preferredembodiment, the isopropyl alcohol further comprises 0.5% methylsalicylate (wintergreen oil).

Step 2: Addition of Remaining Active Components

A quantity of a solution having solubilized potassium iodide and kelpextract is added to the mixture prepared in Step 1 with stirring. Afterthe potassium iodide and kelp extract is incorporated into the mixture,a quantity of citrus oil is added with stirring.

A preferred solution containing potassium iodide and kelp extract hasapproximately 3-4 mg of solubilized potassium iodide and 40-45 mg ofkelp extract per mL of solution. An amount ranging from 2 mL to 6 mL ofthe solubilized potassium iodide/kelp may added to the formulation.

Citrus oil useful for the present formulation is preferably selectedfrom grapefruit essential oil, lemon essential oil, orange essentialoil, and combinations thereof. Preferably the citrus oil will haveapproximately 500 mg to 1000 mg of essential per milliliter. A finalconcentration range of 0.001% to 1.0% of essential oil may be used inthe formulation. More preferably, the final concentration is 0.1% to0.5% by volume.

Step 3: Addition of Solubilized Components to Finalize Volume

After the additional active components in Step 2 have been fullyincorporated into the solubilized starting composition, an additionalquantity of solubilized components is added to reach a final volume of750 mL.

Method of Using Hair Loss Formulation

The method of use for treating hair loss will be the same whether theformulation has been prepared using the dry form or solubilized form ofthe ionic components. The formulation is best dispersed on the scalpwhen a non-aerosol spray device is employed. A spray device thatproduces a fine mist is preferred to ensure even distribution to thescalp and to prevent run-off of the formulation from the scalp. A smallspray bottle with a 4 to 8 ounce volume capacity is preferred for easeof use. Alternatively, the formulation can be applied to the treatmentarea with another application means, such as a sponge.

Treatment Step 1: Cleanse Scalp Area

Prior to applying the hair loss formulation, the scalp area should bethoroughly cleansed and then rinsed to remove any soap residue. Hairshould be dried prior to application of the formulation. Users shouldnot apply any hair products to the scalp, such as hair spray, gels,mousse or other products as these products may leave a reside on thescalp possibly inhibiting the hair loss formulation from contacting thehair follicles in the treatment area.

Treatment Step 2: Application of Formulation to Scalp

The scalp area is lightly sprayed with the hair loss formulation and theformulation is allowed to dry on the scalp. Care should be taken not toover-spray the treatment area to prevent the formulation from runningoff the scalp. Once the first spray of the formulation has dried on thescalp, the formulation can be applied to the scalp a second time in asimilar manner and allowed to dry. After the second application hasdried, the formulation can be applied a third time to the scalp andallowed to dry.

Application of the hair loss formulation according to the above methodmay be repeated one to two additional times throughout the day. It isnot necessary to wash the scalp prior to subsequent treatmentapplications in a single day.

Application of the hair loss formulation according to the above methodshould be continued for at least several months to determine individualefficacy and use may be continued long term to maintain hair growthbenefit.

Example 1: User #1

A male (User #1) with pronounced hair loss on the crown area of thescalp and moderate hair loss on the frontal area of the scalp appliedthe hair spray formulation to the entire scalp area two to three timesper day for 2 years. The user noticed a marked increase in hair growthon the frontal and crown areas of the scalp.

FIG. 1 shows the crown area of the scalp of User #1 after 2 years ofdaily use of the formulation. User #1 found that hair around the baldingarea on the crown was fuller than prior to using the treatment, thediameter of the balding area had decreased, and growth of new hair wasevident in the center portion of the balding area on the crown.

FIG. 2 shows the frontal area of the scalp of User #1 after 2 years ofdaily use of the formulation. User #1 found that hair growth had filledin along the forehead edges where hair had been receding along hairlineand hair on the frontal area of the scalp was fuller than prior to usingthe treatment.

Example 2: User #2

A male (User #2) with substantial hair loss on the frontal, hairline andcrown areas of the scalp applied the hair spray formulation to theentire scalp area daily for 6 months. After six months of daily use ofthe formulation, User #2 found that new hair growth was evident over thebalding area in the crown area and saw significant new hair growth onthe frontal and forehead portions of the scalp.

I claim:
 1. A method of making a composition to treat hair losscomprising: solubilizing a first combination of water-soluble ionizablemetal compounds consisting of potassium phosphate, potassium oxide,potassium chloride, copper ethylenediaminetretraacetic acid (Cu-EDTA),iron hydroxy-2-ethylenediaminetretraacetic acid (Fe-HEDTA), manganeseethylenediaminetretraacetic acid (Mn-EDTA), zincethylenediaminetretraacetic (Zn-EDTA) in a first quantity of purifiedwater; solubilizing a second combination of non-metal ionic compoundsconsisting of ammonium sulfate, urea, and boric acid in a secondquantity of purified water; and combining said solubilized firstcombination and said solubilized second combination with mixing toproduce a solubilized third combination.
 2. The method of claim 1,further comprising: adding a quantity of a short chain alcohol to saidsolubilized third combination.
 3. The method of claim 2, wherein saidshort chain alcohol is selected from ethyl alcohol, isopropyl alcohol,and combinations thereof.
 4. The method of claim 3, wherein saidquantity of short chain alcohol further comprises methyl salicylate. 5.The method of claim 1, wherein said purified water is distilled ordeionized water.
 6. The method of claim 1, further comprising: addingone or more stabilizing components selected from water-soluble polymers,soluble silicates, polysaccharides, gums, celluloses, clays, xanthangum, acacia gum, guar gum, carrageenan, alginic acid, hydroxyethylcellulose, methyl cellulose, pectin, rice starch, wheat starch, cornstarch, aluminum monostearate, polyethylene glycol, sodium silicate,sodium bentonite, attapulgite, and combinations thereof, to said firstcombination of water-soluble ionizable metal compounds prior tosolubilizing in water.
 7. The method of claim 1, further comprising:adding one or more stabilizing components selected from water-solublepolymers, soluble silicates, polysaccharides, gums, celluloses, clays,xanthan gum, acacia gum, guar gum, carrageenan, alginic acid,hydroxyethyl cellulose, methyl cellulose, pectin, rice starch, wheatstarch, corn starch, aluminum monostearate, polyethylene glycol, sodiumsilicate, sodium bentonite, attapulgite, and combinations thereof, tosaid second combination of water-soluble non-metal ionic compounds priorto solubilizing in water.